Following the early scandals, Rhimes explained she had to shift her perspective as the showrunner.

“It was certainly not a challenge I was looking for,” she continued. “It was also not a challenge I expected. When we partnered with [producers] Mark Gordon and [creative partner] Betsy [Beers], I remember thinking, ‘Well, they’ll have to deal with all that stuff and I’ll just write,’ and later realizing that’s absolutely not the way it works.”

According to Rhimes, she soon learned, “If you are the creative brain, you not only have to share your brain with other people, but also everybody looks to you as the leader. I had to figure out how to be a great leader, and that took a while.”

While there’s certainly been drama behind the scenes, read on to see some of the biggest twists and turns throughout Grey’s Anatomy’s 21 seasons.